Synthesis and Antibacterial Activities of New 1β‐Methylcarbapenems Having a 1,3‐Diazabicyclo[3.3.0]octan‐2,4‐dione Moiety
- 1 January 1997
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 330 (8) , 268-270
- https://doi.org/10.1002/ardp.19973300808
Abstract
The synthesis of a new series of 1β‐methylcarbapenems having a 1,3‐diazabicyclo[3.3.0]octane‐2,4‐dione moiety is described. Their in vitro antibacterial activities against both Gram‐positive and Gram‐negative bateria are determined and the effect of substituent on the bicyclic ring as well as stereoisomerism was investigated.Keywords
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