Effect of Thymectomy on Skin-Homograft Survival in Children

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Abstract
RECENT investigations have indicated that the thymus gland has an important role in the initiation of immune potential in animals.1 Specifically, thymectomy in the neonatal period2 , 3 and thymectomy combined with total-body irradiation in adult animals4 have permitted prolonged survival of skin homografts. The latter principle has been utilized in an effort to prolong survival of human adult renal autografts as reported by Starzl et al.5 There is no information available regarding neonatal thymectomy in man, but a study of the effect of thymectomy on skin homografts in immunologically competent children appeared practical from the point of view of clinical transplantation. . . .

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