Phenformin and lactic acidosis.
- 10 January 1976
- Vol. 1 (6001) , 70-72
- https://doi.org/10.1136/bmj.1.6001.70
Abstract
Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for lactic acidosis. Advanced age and cardiovascular and renal disease are absolute contraindications to the use of phenformin in diabetics.Keywords
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