Oxidation of NAD dimers by horseradish peroxidase

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Abstract
Horseradish peroxidase catalyzes the oxidation of NAD dimers, (NAD)2, to NAD in accordance with a reaction that is pH-dependent and requires 1 mol of O2 per 2 mol of (NAD)2. Horseradish peroxidase also catalyzes the peroxidation of (NAD)2 to NAD. In contrast, bacterial [Streptococcus faecalis] NADH peroxidase does not catalyze the peroxidation or the oxidation of (NAD)2. A free-radical mechanism is proposed for both horseradish-peroxidase-catalyzed oxidation and peroxidation of (NAD)2.