ON THE CONTROL OF FOLLICULAR DEVELOPMENT IN INTRASPLENIC OVARIAN GRAFTS BY MINUTE QUANTITIES OF OESTROGEN

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Abstract
Introduction The control of ovarian endocrine function by oestrogen is known since almost twenty years (for references see Courrier 1945; Masson and Barsantini 1948; Robertson 1949). More recently it has been found in this Department that intrasplenic ovarian grafts in the guinea pig offer an excellent opportunity for a systematic study of the steroid control of follicular development dependent on hypophyseal gonadotrophins, the hypophysis being freed from the ovarian control since the steroids produced by the ovary itself are inactivated, when this device is used, in their passage through the liver. Hemorrhagic follicles (H.F.) and cystic follicles which are a characteristic feature of the intrasplenic graft in castrated females failed to appear when oestrogen absorbed from a subcutaneously implanted pellet of α-oestradiol was allowed to circulate in the body; production of corpora lutea was greatly enhanced. On the contrary, progesterone and desoxycorticosterone were shown to counteract luteinization (Lipschutz a. oth. 1948).3

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