General Anaesthesia with Halothane and Drug Absorption: The Effect of General Anaesthesia with Halothane and Diazepam on Postoperative Gastric Emptying in Man

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Abstract
The effect of general anesthesia with halothane on postoperative absorption of paracetamol was measured in 7 patients, after minor surgery on the extremities. Gastric emptying, estimated indirectly by the rise in serum paracetamol following oral administration of the drug, was significantly delayed after general anesthesia with halothane compared with gastric emptying when general anesthesia with halothane was not administered. Absorption of paracetamol and, therefore, gastric emptying were normal or nearly normal when diazepam 15 mg was given orally to the same patients 2 wk later.