Cardiovascular and metabolic responses to noradrenaline in man, before and after acclimatization to cold in Antarctica

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Abstract
Four men of European descent were infused with noradrenaline [norepinephrine] at rates of 0.38, 0.75, 0.150 and 0.300 [mu]g/kg. min. in Australia, and again after 29 wk. residence at Mawson, Antarctica. A concurrent study of their responses to whole-body cooling showed that they acclimatized to cold in Antarctica. Blood pressure rose and heart rate fell in proportion to the dose of norepinephrine infused. The response was much less after than before acclimatization in 3 of the 4 subjects. Subjective effects of the drug decreased in proportion to the decrease in the pressor effect. Finger temperature fell in proportion to the dose infused, in 3 subjects. The response was unchanged or increased after acclimatization. Oxygen consumption was initially unaffected by norepinephrine, but after acclimatization it apparently increased in proportion to the dose infused. The increase in pulmonary ventilation during infusion was slightly greater after acclimatization.