Effect of Serotonin upon Liver Cells of Young Rats.

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Abstract
Summary In young rats weighing less than 115g a single subcutaneous injection of 40 mg/kg or more of serotonin creatinine sulphate resulted in increased formation of hepatic parenchymal cells as demonstrated by autoradiographic technics employing tritiated thymidine. With histologic methods, livers showed an increase in mitotic figures. Slight cytologic changes in hepatic cells were observed, but in no instance was frank cellular necrosis found, even with extremely large doses of serotonin. The mechanism by which serotonin affects hepatic cell formation is not known, although toxic or ischemic effects are considered to be the most probable explanation.