Vasopressin-induced changes in receptor-mediated endocytosis of asialoglycoprotein in rat hepatocytes
- 1 January 1991
- journal article
- Published by Wiley in Biology of the Cell
- Vol. 73 (1) , 43-47
- https://doi.org/10.1016/0248-4900(91)90007-a
Abstract
The ability of second messengers to modulate receptor-mediated endocytosis was studied on isolated rat hepatocytes. A 20-min preincubation with vasopressin was used as a modulation. We observed a 20% inactivation of both surface and intracellular receptors, with no change in the affinity of those remaining active. The internalization and dissociation of a synchronous wave of ligand was not affected, but its degradation was partially inhibited. Our observations suggest that second messengers such as intracellular calcium and diacylglycerol play a complex role in the intracellular trafficking associated with endocytosis.Keywords
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