Tentative interpretive criteria and quality control parameters for in-vitro susceptibility testing of Neisseria gonorrhoeae to two fluoroquinolones (PD 131628 and grepafloxacin (OPC 17116))
Open Access
- 1 January 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 37 (1) , 139-143
- https://doi.org/10.1093/jac/37.1.139
Abstract
The susceptibility of Neisseria gonorrhoeae to PD 131628 and grepafloxacin (OPC 17116) was evaluated by agar dilution and disc diffusion methods. A tentative susceptibility category for both fluoroquinolones included strains for which the MICs are ≤0.06mg/L and the zones of inhibition are ≥38mm for PD 131628 and ≥37 mm for grepafloxacin. Quality control studies with N. gonorrhoeae ATCC 49226 suggested that agar dilution MIC limits were 0.002–0.008 mg/L and 0.004–0.03 mg/L for PD 131628 and grepafloxacin, respectively. The zone size limits were 50–58 mm for PD 131628 and 44–52 mm for grepafloxacin.Keywords
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