The organisation of the mouse secretogranin II gene
- 17 December 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 314 (3) , 375-380
- https://doi.org/10.1016/0014-5793(92)81509-k
Abstract
We have characterized the gene which encodes mouse secretogranin II (previously also referred to as chromogranin C), a tyrosine‐sulfated secretory protein belonging to the granin (chromogranin/secretogranin) family which is found in secretory granules of most endocrine cells and neurons. The secretogranin II gene was found to contain 2 exons. In contrast to chromogranin A and chromogranin B, the two previously characterized granin genes, the entire secretogranin II protein is encoded by a single exon, exon 2, with exon 1 containing only a 5′‐untranslated sequence. Consistent with previous data on the expression of secretogranin II, the putative promoter region was found to contain a cAMP‐responsive element and a potential AP‐1 binding site.Keywords
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