Permeability of liposomal membranes composed of unnatural types of synthetic lecithin-analogues.

Publisher Website
Google Scholar
Abstract
The permeability properties of liposomal membranes composed of synthetic unnatural type phospholipids are compared with those of the corresponding glyceride-type lecithins. Some of the synthetic analogs can retain glucose in the liposomes in nearly the same way as that in the saturated long-chain lecithin-derived liposomes. Cholesterol fluidizing effect of the lecithin analogs was generally small compared with those of the corresponding lecithins, partly due to bulkiness of the trichloromethyl group which may hinder the immobilization of cholesterol along the fatty acid chains. The liposomes derived from enol-type synthetic lipid can regain the barrier ability at the temperatures above the transition temperature just as natural unsaturated-chain lecithins do.

This publication has 1 reference indexed in Scilit: