A new, general synthesis of purines
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 14,p. 1547-1550
- https://doi.org/10.1039/p19760001547
Abstract
Reactions of 6-amino-5-nitrosouracil derivatives with the 1,1-dimethylhydrazones of a wide variety of aldehydes in dimethylformamide led to the corresponding xanthine derivatives. Alkylation of 9-substituted 1-methyl-xanthines with an excess of alkyl halide in dimethylformamide in the presence of potassium carbonate gave the corresponding 3,7-dialkyl-1-methylxanthine, with elimination of the 9-substituent. Treatment of 6-amino-4-hydroxy-5-nitroso-2-phenylpyrimidines with aldehyde 1,1-dimethylhydrazones also gave the corresponding purines.This publication has 0 references indexed in Scilit: