Rhodamine B (RB), Rhodamine 6G (R6G), Oxazine 4 perchlorate (O4PC), and 4-Dicyanomethylene-2-methyl-6-(p-dimethylaminostyryl-4H-pyran)-doped graded-index (GI) polymer optical fiber amplifiers (POFA’s) were successfully prepared by novel techniques to prevent degradation of organic dyes and to enhance solubility of the dyes in methyl methacrylate and in poly(methyl methacrylate) (PMMA). High-power (620 W) and high-gain (33-dB, 2070 times) amplification was achieved for RB-doped GI POFA’s based on the spectral investigation of dyes in PMMA bulk. It should be noted that amplification in the low-loss region of polymer optical fibers was achieved in the R6G- and O4PC-doped GI POFA.