Fragmentation of Immunoglobulin G in Immune Serum Globulin

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Abstract
IT is generally believed that immune serum globulin (ISG),‡ often loosely referred to as "gamma globulin," is very stable. On the basis of antibody assays and physicochemical tests used in the past, opinions have been ventured that its half-life in storage at 4°C. in the powder or liquid form is between seventeen and twenty-five years. However, in 1960 Škvařil1 reported that the immunoelectrophoretic pattern of ISG changes during storage. The gamma-globulin (IgG) band is gradually replaced by 2 bands, suggesting a fragmentation of the immunoglobulin molecule similar to that observed after digestion with papain. Confirmation of this observation has since . . .

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