Low and high frequency stimulation tests to characterize the effects of edrophonium on vecuronium-induced neuromuscular block
Open Access
- 1 January 1995
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 74 (1) , 12-15
- https://doi.org/10.1093/bja/74.1.12
Abstract
We recorded adductor pollicis mechanical activity in response to low (0.1 and 2 Hz) and high (50 and 100 Hz) frequency stimulation 15min after edrophonium 250, 500 and 1000 μg kg−1, given to antagonize vecuronium-induced block at 10, 25 and 50% pre-reversal twitch height. We studied 54 ASA class I and II anaesthetized (methohexitone, fentanyl, nitrous oxide) young adult patients allocated randomly to nine groups of six patients each. The greater sensitivity of train-of four (TOF) ratio and residual force after 100-Hz, 5-s tetanic stimulation (RF100) to residual deficit allowed discrimination more readily between the effects of edrophonium dose and pre-reversal twitch height (P < 0.001, two-way analysis of variance). The highest reversal scores (approximately 0.9 TOF ratio and 0.6RF100) were obtained when edrophonium 500–1000 mg kg−1 was given at 50% twitch height (P < 0.05, Duncan's test).Keywords
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