Marine Natural Products. XXXIII. Theonellapeptolide IId, a New Tridecapeptide Lactone from the Okinawan Marine Sponge Theonella swinhoei.

1 January 1994

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 42 (7) , 1410-1415
https://doi.org/10.1248/cpb.42.1410

Abstract

Following the characterization of theonellapeptolides Ia-Ie (2-6), another new tridecapeptide lactone named theonellapeptolide IId (1) was isolated from the Okinawan marine sponge Theonella swinhoei. The structure of 1 has been determined on the bases of chemical and physicochemical examinations which included an HPLC-CD combined analysis of the amino acid composition. Theonellapeptolide IId (1) prevented fertilization of the sea urchin Hemicentrotus pulcherrimus at the concentration of 25 micrograms/ml or greater but did not affect early embryonic development of fertilized eggs up to the gastrula stage.

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