Lesion of serotonergic neurons antagonizes clonidine-induced suppression of avoidance behavior and locomotor activity in rats
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 73 (3) , 261-264
- https://doi.org/10.1007/bf00422414
Abstract
The effects of clonidine on avoidance acquisition and locomotor activity were studied in male Wistar rats with 5,6-dihydroxytryptamine (5,6-DHT) lesions of the median raphe nucleus. Lesioned animals showed marked depletion in forebrain serotonin and 5-hydroxyindole acetic acid concentrations. Clonidine (0.2 mg/kg IP in a single daily dose for 6 consecutive days) inhibited avoidance acquisition and reduced locomotor activity in unlesioned rats. In 5,6-DHT rats clonidine failed to produce depressive effects. The resistance of raphe-lesioned rats to clonidine is discussed on the basis of possible interaction between noradrenergic and serotonergic brain systems.This publication has 27 references indexed in Scilit:
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