Experimental Design for a Granulation Process with “Priori” Criterias

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Abstract
Optimization techniques representr analytical tools available for the best solution to a particular problem. Pharmaceutical product and process design problems were structured as constrained optimization problems and subsequently solved by the “a priori” optimality approach using an exchange algorithm. The effect of the amount of added water plus granulation time and impeller speed on two properties of the granulates were investigated. Experimental results obtained for the optimal formulation agreed well with the predictions.

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