Uptake of Rat Gastric-Juice-Bound Vitamin B12by Intestinal Brush Borders Isolated from Blind-Loop Rats

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Abstract
Rats with experimental self-filling jejunal blind loops had raised excretion of urinary indican and fecal fat and decreased vitamin B12 absorption. Vitamin B12 uptake by brush borders isolated from the middle segment of rat small intestine was measured. Rat gastric juice enhanced vitamin B12 uptake by brush borders both from blind-loop rats and control rats, and there was no significant difference in the uptake of rat gastric-juice-bound vitamin B12 by brush borders from blind-loop rats and control rats. These results do not support the hypothesis that bacteria cause B12 malabsorption in the stagnant-loop syndrome by interference with B12 uptake by intestinal epithelial cells.