INFLUENCE OF BILIARY DISEASE ON EXCRETION OF CEFAZOLIN IN HUMAN BILE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 81  (4) , 426-430
Abstract
Patients (45) with varying biliary pathology were injected with 1 g of i.m. cefazolin sodium prior to surgery. Serum, gallbladder bile and common duct bile levels were measured. The type of biliary disease did not influence serum levels (mean, 29 .mu.g/ml) which reached a peak 1 h after injection. Mean common duct bile levels were reduced from 52 .mu.g/ml in nonjaundiced patients to 4 .mu.g/ml in those with jaundice (P < 0.001). Patients with radiologically functioning gallbladders had significantly higher mean gallbladder bile levels (21 .mu.g/ml; P < 0.005). The mean gallbladder bile level in acute cholecystitis was 25 .mu.g/ml. As the minimum inhibitory concentration of cefazolin for organisms commonly found in the bile is 0.5-6 .mu.g/ml, cefazolin sodium may be of value in the treatment of biliary disease, particularly acute cholecystitis.

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