COMPARATIVE EFFECTS OF 2 DOSES OF GLIBENCLAMIDE UPON METABOLIC RHYTHMS IN MATURITY-ONSET DIABETICS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 4  (3) , 175-180
Abstract
Maturity-onset diabetics [5] were studied during therapy with glibenclamide 2.5 mg and 5 mg sampling blood every 1/2 h for 12h. All patients had lower mean blood glucose concentrations during therapy with 5 mg glibenclamide. There was no significant difference between serum insulin concentrations on the 2 doses, however, the serum insulin/blood glucose ratio was higher during the larger dose of glibenclamide. Mean blood lactate, pyruvate and serum triglycerides were significantly lower, and blood glycerol, 3-hydroxybutyrate, and plasma non-esterified fatty acids were increased during therapy with 5 mg. In the individual patient, the changes in blood glycerol and plasma non-esterif-ed fatty acids were related to changes in circulating insulin concentration and did not appear to be a true extra-pancreatic effect of glibenclamide. The mechanism of any extra-pancreatic effect remains unclear.