LOCAL CEREBRAL CONSUMPTION OF GLUCOSE IN THE MOUSE - ADAPTATION OF THE C-14 DEOXYGLUCOSE METHOD TO FREE-MOVING SMALL MAMMALS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 293  (1) , 79-83
Abstract
Local cerebral glucose utilization (LCGU) was measured with the [14C] deoxyglucose ([14C] DG) method in the awake, free moving mouse. Values vary from 112 .mu.mol/100 g per min in the superior colliculus, the most active structure, to 22 .mu.mol/100 g per min in the internal capsule. Glucose consumption is high in fasciculus retroflexus, a result peculiar to the mouse when compared to other mammals studied with this method. The modifications in plasma sampling proposed should facilitate the use of the [14C] DG method in free moving animals as small as the mouse, and allow for the study of the effects of behavior on local cerebral energy consumption.