Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.
- 15 August 1992
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 89 (16) , 7630-7634
- https://doi.org/10.1073/pnas.89.16.7630
Abstract
Reactivation of latent virus is believed to result from a signal transduction event that induces immediate-early (IE) gene transcription. Evidence is presented that the major IE promoter (MIEP) of human cytomegalovirus (hCMV) is activated by physiological levels of retinoic acid (RA) in human embryonal carcinoma cells. Mutagenesis experiments localized in the MIEP enhancer, a retinoic acid-responsive element composed of a direct repeat separated by five nucleotides. Protein-DNA binding experiments revealed that this element functions as a specific target site for the direct interaction of nuclear receptor proteins for RA. These findings implicate the biologically active derivative of vitamin A (RA) as a potential modulator of hCMV pathogenesis in infants and immunocompromised adults.Keywords
This publication has 40 references indexed in Scilit:
- Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptorsCell, 1991
- Nuclear receptors enhance our understanding of transcription regulationTrends in Genetics, 1988
- A human retinoic acid receptor which belongs to the family of nuclear receptorsNature, 1987
- Differentiation of TERA-2 human embryonal carcinoma cells into neurons and HCMV permissive cellsDifferentiation, 1986
- Retinoic Acid EmbryopathyNew England Journal of Medicine, 1985
- Cytomegalovirus Replicates in Differentiated But Not in Undifferentiated Human Embryonal Carcinoma CellsScience, 1984
- Prenatal Cytomegalovirus Disease and Cerebral Microgyria: Evidence for Perfusion Failure, not Disturbance of Histogenesis, as the Major Cause of Fetal Cytomegalovirus EncephalopathyNeuropediatrics, 1984
- TERATOGENICITY OF ISOTRETINOINThe Lancet, 1983
- Excess vitamin A and development of the cerebral cortexJournal of Comparative Neurology, 1967
- MICROGYRIA AND CYTOMEGALIC INCLUSION DISEASE IN INFANCYJournal of Clinical Pathology, 1959