Nicotinamide prevents the development of cyclophosphamideinduced diabetes mellitus in male non-obese diabetic (NOD) mice

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Abstract
Single intraperitoneal administration of cyclophosphamide (200 mg/kg) to male nonobese diabetic (NOD) mice resulted in a significant increase in the incidence of overt diabetes mellitus up to 90% around 2 weeks alter the injection (PP<0.005). Pancreatic islets of cyclophosphamide-nicotinamide-treated 19-week-old mice were normal in size, but were slightly or moderately infiltrated by lymphocytes. In contrast, only small-sized islets were left in cyclophosphamide-induced diabetic mice of the same age, and some of these islets were severely affected by insulitis.