Retinal Morphological Changes of Patients With X-linked Retinoschisis Evaluated by Fourier-Domain Optical Coherence Tomography

Abstract
Cases of retinoschisis or splitting of the retina were mentioned as early as 1898.1 More than 100 years later, our knowledge about X-linked retinoschisis (XLRS) incidence, histopathological features, causative genes, and possible gene-protein interaction has advanced greatly.2 A recent study by Apushkin et al3 suggested that visual acuity does not correspond to the size of cystic areas or retinal thickness as evaluated by time-domain optical coherence tomography (OCT). The question of why patients with XLRS have varying levels of reduced vision remains unanswered.