Synthesis and Properties of 7‐Substituted 7‐Deazapurine (Pyrrolo[2,3‐d]pyrimidine) 2′‐Deoxyribonucleosides
Open Access
- 1 June 2005
- journal article
- unit
- Published by Wiley in Current Protocols in Nucleic Acid Chemistry
- Vol. 21 (1) , 1.10.1-1.10.20
- https://doi.org/10.1002/0471142700.nc0110s21
Abstract
7‐Substituted 7‐deazapurine (pyrrolo[2,3‐d]pyrimidine) 2′‐deoxyribonucleosides are synthesized by stereoselective nucleobase anion glycosylation. The introduction of a halogen at C7 is performed regioselectively either on the nucleobase or on the nucleoside. The pKa values of a series of 7‐deazapurine 2′‐deoxyribonucleosides are provided, and fluorescence properties are also discussed.Keywords
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