PHARMACOKINETICS OF SULPIRIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION IN RAT AND DOG

  • 1 January 1976
    • journal article
    • research article
    • Vol. 223  (1) , 88-95
Abstract
The plasma concentration of sulpiride was measured in the rat and in the dog after oral and i.v. administration of the drug. In the rat only traces (< 1 .mu.g/ml) of sulpiride were detected in plasma after an oral dose of 100 mg/kg. The peak concentrations in 3 dogs given 25, 50 or 100 mg/kg orally were 6.1, 15.6 and 23.9 .mu.g/ml, respectively. The pharmacokinetic data after i.v., injection were compared to earlier observations with the related orthopramide compound, metoclopramide. The half-life of sulpiride in dog plasma (1.6-3.4 h) is longer than that of metoclopramide, but in the rat there is little difference between the 2 compounds. Both of the compounds have large total apparent volumes of distribution (1-2 l/kg) in the 2 species. The marked species difference in the systemic bioavailability of oral sulpiride should be taken into account when the orthopramide drugs are evaluated in pharmacological tests.

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