Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats
- 1 February 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (2) , 287-289
- https://doi.org/10.1093/carcin/5.2.287
Abstract
Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality ( p < 0.01) and a greater incidence of metastases compared to untreated animals with the same stage of disease. It is postulated that indomethacin might have a promotional effect on the spread of autochthonous experimental colon cancer.Keywords
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