Action of Tsoprenaline, Isoxsuprine and Ritodrine in the Human Non–pregnant Myometrium

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Abstract
The effects of isoprenaline, isoxsuprine and ritodrine were tested on spontaneously contracting muscle strips from non–pregnant human uterus in vitro. The strips were rather insensitive to all three drugs, the maximal inhibitions obtained being: isoxsuprine (10–4 M) 81 %, ritodrine (10–4 M) 45 %, isoprenaline (10–5 M) 19%. Propranolol 3.4 × 10–6 M did not significantly block the effects of isoxsuprine and ritodrine. It is concluded that the non–pregnant human uterus is rather insentitive to β–adrenoceptor stimulation, and that isoxsuprine and ritodrine act mainly through unspecific mechanisms.