Multiple Forms of Thymidine Kinase during Human Development

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Abstract
The developmental progression of thymidine kinase from the electrophoretically slow-migrating ‘fetal’ forms to the fast-migrating ‘adult’ form was examined in human serum and fetal liver. In fetal liver, only the fetal forms of the enzyme were present at 17 weeks’ gestation. A transitional period followed in that both enzyme forms were identified and by 24 weeks only the adult form was detected in fetal liver. This same enzyme changeover pattern – fetal to transitional to adult – occurred at a later time in human serum as it took place between 30 and 40 weeks’ gestation.