Centromeres from telomeres? The centromeric region of the Y chromosome of Drosophila melanogaster contains a tandem array of telomeric HeT-A- and TART-related sequences
Open Access
- 1 August 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 27 (16) , 3318-3324
- https://doi.org/10.1093/nar/27.16.3318
Abstract
Cytological and cytogenetic studies have previously defined the region needed for centromeric function in the Y chromosome of Drosophila melanogaster. We have identified a YAC clone that originated from this region. Molecular analysis of the YAC and genomic DNAs has allowed the description of a satellite DNA made of telomeric HeT-A- and TART-derived sequences and the construction of a long-range physical map of the heterochromatic region h18. Sequences within the YAC clone are conserved in the centromeric region of the sibling species Drosophila simulans. That telomere-derived DNA now forms part of the centromeric region of the Y chromosome could indicate a telomeric origin of this centromere. The existence of common determinants for the function of both centromeres and telomeres is discussed.Keywords
This publication has 42 references indexed in Scilit:
- Construction of YAC–based mammalian artificial chromosomesNature Biotechnology, 1998
- Neocentromere activity of structurally acentric mini-chromosomes in DrosophilaNature Genetics, 1998
- Molecular Structure of a Functional Drosophila CentromereCell, 1997
- A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNANature Genetics, 1997
- Formation of de novo centromeres and construction of first-generation human artificial microchromosomesNature Genetics, 1997
- Localization of centromere function in a drosophila minichromosomeCell, 1995
- A novel epigenetic effect can alter centromere function in fission yeastCell, 1994
- Dissecting the centromere of the human Y chromosome with cloned telomeric DNAHuman Molecular Genetics, 1994
- Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomesNature Genetics, 1993
- A Correlation of Ring-Shaped Chromosomes with Variegation in Zea MaysProceedings of the National Academy of Sciences, 1932