EFFECT OF PROPHYLAXIS WITH LOW-DOSE HEPARIN ON BLOOD-COAGULATION PARAMETERS - DOUBLE-BLIND STUDY IN CONNECTION WITH TRANSVESICAL PROSTATECTOMY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 41  (2) , 337-345
Abstract
Heparin was administered s.c. 5.000 IU twice daily using a double blind method to 10 of 21 patients undergoing transvesical prostatectomy. Platelet count, APTT [activated partial thromboplastin time], thrombin time, Reptilase time, Normotest, fibrinogen, factor-VIII, ethanol gelation test, antithrombin III, fibrinolytic degradation products, .alpha.1-antitrypsin and .alpha.2-macroglobulin were studied pre- and postoperatively up to the 10th postoperative day. Statistical analysis of parameters of blood coagulation and fibrinolysis showed no significant difference between the 2 groups. The mechanism by which low dose heparin exerts its thromboprophylactic effect could not be elucidated from the study of the investigated parameters. The laboratory data gave no indication to a possible increased risk of postoperative hemorrhage.