Seasonal Variation of Serum Thyrotropin Concentration and Thyrotropin Response to Thyrotropin-Releasing Hormone in Patients with Primary Hypothyroidism on Constant Replacement Dosage of Thyroxine*

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Abstract
Ten patients with primary hypothyroidism (aged 32–66 yr), replaced on constant daily doses of L-T4 (mean ± SD, 1.90 ± 0.22 μg/kg BW), were used to examine seasonal variations in serum levels of thyroid-related hormones for a period of 14 months. Basal and peak TSH concentrations after TRH (500 μg) were higher in winter than in summer. Summer values for basal TSH were all normal (normal range, 3 uptake, T4, free T4 index(FT4I), T3, free T3 index, and rT3 levels did not vary seasonally, although T4 and FT4I tended to fall in the winter. The summer and winter QKd interval (the interval from the onset of a QRS complex in the electrocardiogram to the appearance of the Korotkoff sound at diastolic pressure), basal metabolic rate, and serum cholesterol concentrations were all within the normal range. Basal and peak TSH after TRH were inversely correlated with serum T4 and FT4I levels. The basal TSH concentration was further inversely correlated with the seasonally altering ambient temperature. These results indicate that during the treatment of primary hypothyroidism with constant doses of T4, 1) serum TSH and its response to TRH show seasonal variation, 2) the hypersecretion TSH in the winter is related to small changes in serum T4 and FT41 levels, and 3) the seasonal variation in the serum TSH concentration may need to be taken into consideration when evaluating the adequacy of a T4 replacement dose. (J Clin Endocrinol Metab54: 1118,1982)