Mechanisms of Lithium Action
- 2 August 1973
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 289 (5) , 254-260
- https://doi.org/10.1056/nejm197308022890508
Abstract
LITHIUM first attracted medical attention in the 19th century when A. B. Garrod attempted to treat gout with Li+ because Li+ urate was found to be more soluble than Na+ or K+ urate. However, the ubiquity of Na+ and K+ in human fluids prevented successful clinical exploitation of the differential solubility. Since that time the medical applications of Li+ have ranged from use as a sodium substitute to improve taste in low Na+ diets to use as a psychoactive agent in the treatment of manic-depressive disorders. The corresponding results have ranged from the production of severe and occasionally fatal Li . . .Keywords
This publication has 6 references indexed in Scilit:
- Serum Thyrotropin and Thyroxine Concentrations in Patients Receiving Lithium CarbonateJournal of Clinical Endocrinology & Metabolism, 1973
- The Use of Lithium in the Treatment of ThyrotoxicosisJournal of Clinical Investigation, 1972
- Effect of lithium on plasma cortisol and adrenal response to adrenocorticotropin in manClinical Pharmacology & Therapeutics, 1972
- Lithium-induced nephrogenic diabetes insipidus: in vivo and in vitro studiesJournal of Clinical Investigation, 1972
- LithiumAnnual Review of Pharmacology, 1971
- The effect of NaCl and LiCl on vasopressin-sensitive adenyl cyclaseLife Sciences, 1970