EVIDENCE AGAINST AN ALDOSTERONE FEED-BACK MECHANISM WITHIN THE ADRENAL GLAND

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Abstract
Experiments were made on conscious undisturbed sheep with autotransplants of the adrenal gland. Large local increase of the aldosterone concentration of adrenal arterial blood was made for 2–6 hours in Na replete and Na deficient sheep. The results did not indicate that the secretion of aldosterone which occurs in response to concurrent lowering of Na and increase of K concentration of adrenal arterial blood in Na replete sheep, or in Na deficiency was significantly modified by the local increase of aldosterone in adrenal arterial blood.

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