The effect of secretin on bile production, splanchnohepatic hemodynamics and liver function in cats

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Abstract
The effect of secretin on bile flow, biliary clearance of 14C-erythritol and bile composition was studied in fasting, chloralose anesthetized cats. Secretin (2 U[units].cntdot.kg-1.cntdot.h-1) increased bile flow by 85% and increased the rates of excretion of Na+, Cl- and .**GRAPHIC**. Bile flow increased from values below to values above the erythritol clearance, which did not change significantly. Secretin altered ductular transfer of fluid from a net reabsorption to a net secretion of a bicarbonate-rich fluid. Secretin did not affect the splanchno-hepatic hemodynamics or the overall function of the liver and indomethacin did not significantly alter the response to secretin.