THE INCORPORATION OF TRITIATED URIDINE IN THE GENITAL TRACT OF THE OESTROGEN-TREATED MOUSE

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Abstract
SUMMARY: The uptake of uridine in vivo into uterine and vaginal RNA after intravenous administration provides a sensitive measure of early oestrogenic effects in the ovariectomized mouse. The response of the uterus to a dose of 0·05 μg. of oestradiol increases rapidly to about tenfold at 8–16 hr., and returns to control levels by 32 hr. In the vagina the response develops more slowly, being maximal at 16–24 hr. The relative potencies of oestradiol, oestrone, oestriol, diethylstilboestrol and meso-hexoestrol tested by this criterion at 4 hr. were similar to those obtained in the 6-hr. water imbibition test.