Aldosterone secretion and plasma renin during renin infusion and acute salt depletion

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Abstract
Unanesthetized dogs were infused with increasing amounts of exogenous hog renin, and the dose-response relationship between arterial renin activity and aldosterone secretion was determined. Over the entire physiological range of plasma renin activities, a further increase in plasma renin produced an increase in aldosterone secretion. The slope of the relationship was highly variable among animals. Porter-Silber chromagen secretion was not altered. Mean arterial blood pressure also showed a consistent dose-response dependency on plasma renin. In the same dogs, renin secretion was acutely increased by inducing rapid salt depletion using the mercurial diuretic meralluride, and plasma renin activity and aldosterone secretion were measured. The dose-responses to exogenous renin infusion and acute salt depletion were quantitatively similar. Porter-Silber chromagen secretion and plasma Na and K concentrations were unchanged by the salt depletion. These data support the hypothesis that the renin angiotensin system is the primary regulator of aldosterone secretion during acute salt depletion in dogs.

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