Spruce budworm (Choristoneura fumiferana) antifeedants 4. Synthesis of specionin and biological studies

Abstract
Specionin (1) was synthesized in seven steps from aucubin (2), an abundant iridoid form aucuba japonica. In a "no-choice" bioassay, specionin and several of its derivatives showed only modest antifeedant activity against the spruce budworm, while other derivatives were devoid of activity.

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