Mutagenicity of ozone in different repair-deficient strains of Escherichia coli
- 1 November 1984
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 197 (3) , 472-477
- https://doi.org/10.1007/bf00329945
Abstract
The mutagenic activity of ozone was investigated by the isolation of streptomycin-resistant mutants (Sm1) in different strains of Escherichia coli. RecA, lexA, polA and parental strains were ozonated and streptomycin-resistant mutants were scored after a short or long phenotypic delay. Our results suggest that ozone is an active mutagen for forward mutation and that this oxidizing agent could be able to induce mutations via two mechanisms: directly and indirectly by the rec-lex error-prone repair system.Keywords
This publication has 64 references indexed in Scilit:
- Ozone-induced DNA degradation in different DNA polymerase I mutants of Escherichia coli K12Biochemical and Biophysical Research Communications, 1977
- Misrepair of overlapping daughter strand gaps as a possible mechanism for UV induced mutagenesis in UVR strains of Escherchia coli: A general model for induced mutagenesis by misrepair (SOS repair) of closely spaced DNA lesionsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- The effect of low concentrations of ozone on Escherichia coli chromosomeMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Optimal conditions for mutagenesis by ozone in Escherichia coli K12Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- Inhaled ozone as a mutagen: I. Chromosome aberrations induced in Chinese hamster lymphocytesEnvironmental Research, 1971
- Repair deficiency in a bacterial mutant defective in DNA polymeraseBiochemical and Biophysical Research Communications, 1970
- RADIOMIMETIC TOXICITY OF OZONISED AIRThe Lancet, 1964
- Ozone-induced Chromosome Breakage in Human Cell CulturesNature, 1962
- Dose-Survival Curves of Human Cells in Tissue Culture Irradiated with Alpha-, Beta-, 20-KV. X- and 200-KV. X-RadiationNature, 1962
- A Comparison of the Bactericidal Activity of Ozone and Chlorine against Escherichia coli at 1Journal of General Microbiology, 1956