AUTO-RHYTHMOMETRY IN MANIC-DEPRESSIVES

  • 1 January 1975
    • journal article
    • research article
    • Vol. 2  (4) , 325-335
Abstract
Three manic-depressives were studied longitudinally. Several times a day, the patients measured and recorded their mood, vigor, oral temperature, finger counting, blood pressure, pulse rate and urine volume. The acrophases of their circadian rhythms were computed by a least-squares fit. These patients displayed rhythm phases that were grossly abnormal. Systematic acrophase changes over time supported the hypothesis that manic-depressives have circadian rhythms that free-run faster than 1 cycle/24 h. Li appeared to show these rhythms and help the environmental synchronizer force physiological functions to coordinate better with the usual 24 h environmental cycles.

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