EFFECT OF OIL-ATTACHED BCG CELL-WALL SKELETON ON INDUCTION OF PLEURAL FIBROSARCOMAS IN MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (3) , 441-445
Abstract
The effect of oil-attached BCG cell wall skeleton on the induction of pleural fibrosarcomas by 3-methylcholanthrene in mice was examined. Pleural fibrosarcomas were induced by a substernal injection of 3-methylcholanthrene into the thoracic cavity of ddO mice. One week after the injection of 3-methylcholanthrene, 100 .mu.g of oil-attached BCG cell wall skeleton was injected s.c. every week for 10 wk. In the observation period of 130 days the incidence of pleural fibrosarcoma was 67% in the control mice and 39% in the mice treated with BCG cell wall skeleton. The latent period of tumor induction was prolonged in mice treated with BCG cell wall skeleton.

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