Novel Purine Nitrile Derived Inhibitors of the Cysteine Protease Cathepsin K
- 23 October 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 47 (24) , 5833-5836
- https://doi.org/10.1021/jm0493111
Abstract
Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.Keywords
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