Cellular schwannoma: a distinct pseudosarcomatous entity

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Abstract
Eighteen cases of cellular schwannoma, a recently delineated benign entity, are described. These tumours present most often in middle‐aged adults of either sex and show a predilection for the paravertebral region of the mediastinum and retroperitoneum. More than half the tumours macroscopically arose from a nerve but none was associated with von Recklinghausen's disease. The light microscopic features are remarkably consistent but are not immediately recognizable as neural in type. Means of distinction from a malignant nerve sheath tumour and from a variety of other soft tissue tumours are discussed. Immunohistochemical positivity for S‐100 protein has been demonstrated in 17 of the 18 cases. Prolonged follow‐up has revealed local recurrence in only one case; none has metastasized.