Crystal Structure of Artemisinic Acid: A Possible Biogenetic Precursor of Antimalarial Artemisinin from Artemisia annua
- 1 February 1993
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 56 (2) , 215-219
- https://doi.org/10.1021/np50092a005
Abstract
Artemisinic acid [1], a possible biogenetic precursor of the antimalarial artemisinin [2], was isolated from the hexane extract of Artemisia annua. X-ray crystallography of the dimer of artemisinic acid shows that the cyclization during intermolecular hydrogen bonding occurs by the opposite orientation of the alpha, beta-methylene group in each molecule. Complete spectroscopic data of 1 are also given.Keywords
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