Comparative metabolism and excretion of adriamycin in man, monkey, and rat
- 1 June 1979
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 2 (2) , 121-125
- https://doi.org/10.1007/bf00254084
Abstract
Summary Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.Keywords
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