Effects of Rat Atrial Extract on Sodium Transport and Blood Pressure in the Rat

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Abstract
Atrial cardiocytes contain specific atrial granules (SAG) which are the storage site of atrial natriuretic factor (ANF). It was determined whether ANF produces natriuresis by inhibiting Na+-K+ pump activity and whether this factor is similar to the humoral Na transport-inhibiting factor (HSTIF) previously demonstrated in acutely volume-expanded animals and humans as well as in experimental and human essential hypertension. In contrast to the HSTIF, ANF does not inhibit membrane Na+, K+-ATPase, vascular smooth muscle cell Na+-K+ pump activity or Na transport in the toad bladder. Infusion i.v. of ANF in the bilaterally nephrectomized, hexamethonium-treated rat produces only a small transient pressor response, probably due to potentiation of endogenous norepinephrine. Apparently the ANF is not the same as the HSTIF detected on acute volume expansion and in some forms of hypertension. Apparently the diuretic and natriuretic effects of ANF are due to mechanism(s) other than blood pressure elevation and inhibition of Na+-K+ pump activity.

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