Discrete Start Sites for DNA Synthesis in the YeastARS1Origin
- 2 January 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 279 (5347) , 95-98
- https://doi.org/10.1126/science.279.5347.95
Abstract
Sites of DNA synthesis initiation have been detected at the nucleotide level in a yeast origin of bidirectional replication with the use of replication initiation point mapping. TheARS1origin ofSaccharomyces cerevisiaeshowed a transition from discontinuous to continuous DNA synthesis in an 18–base pair region (nucleotides 828 to 845) from within element B1 toward B2, adjacent to the binding site for the origin recognition complex, the putative initiator protein.Keywords
This publication has 25 references indexed in Scilit:
- ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genomeCell, 1995
- Two steps in the assembly of complexes at yeast replication origins in vivoCell, 1994
- Yeast origin recognition complex is involved in DNA replication and transcriptional silencingNature, 1993
- ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexNature, 1992
- A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional ElementsScience, 1992
- S Phase of the Cell CycleScience, 1989
- Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori regionCell, 1982
- RNA primers in SV40 DNA replication: identification of transient RNA-DNA covalent linkages in replicating DNABiochemistry, 1977
- Discrete sizes of replication intermediates in drosophila cellsCell, 1977
- Regulation of λ exonucleaseJournal of Molecular Biology, 1966