Apoptosis of murine BW 5147 thymoma cells induced by dexamethasone and ?-irradiation

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Abstract
The mode and the kinetics of the death of T-thymoma cells upon dexamethasone treatment and γ-irradiation (10Gy) have been studied using flow cytometry and biochemical analysis. It has been shown that the hormone and γ-irradiation induce cell death by apoptosis. In both cases the cells are initially blocked in G2/M and die only after overcoming the blockage and cytokinesis. A short exposure to dexamethasone results in a cytostatic effect, whereas a cytotoxic effect is absent. Reducing serum concentration to 2% causes more rapid death both following γ-irradiation and dexamethasone. These results are discussed in relation to cell death and proliferation.